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Paez and Estaeban70 also noted the resistance of vaccinia virus to interferon but obtained evidence that resistance was related to inhibition of the 2-5A system by intervention f a vaccinia viral ATPase (that would block production of 2-5A from the synthetase) and a viral phosphatase that would 50 -dephosphorylate biologically active 2-5A 50 -mono-, di-, and triphosphates Similarly, novel oligoadenylates of unknown structure and unable to activate RNase L accumulate in interferon-treated SV-40 virus-infected monkey CV-1 cells71 Some of the 20 ,50 -oligoadenylates corresponded to nonphosphorylated cores, (A20 p)nA, but a considerable amount eluted in the HPLC at retention times intermediate between ppp(A20 p)3A and cores The unknown peaks did not seem to be changed upon digestion with alkaline phosphatase, implying the lack of terminal phosphate residues Poly(I) poly(C) addition to interferon-treated CV-1 cells gave high levels of authentic biologically active 2-5A.

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In yet another apparent virus-related evasion of the 2-5A pathway, Cayley et al56 noted that in human Chang cells herpes simplex viruses 1 and 2 (HSV-1 and HSV2) were much more resistant to interferon s antiviral action than was encephalomyocarditis virus In all the above cases of interferon virus (HSV-1, HSV-2 or EMCV)-infected cells, similar amounts of 20 ,50 -oligoadenylates were synthesized, but in the instances of HSV-1 and HSV-2 infections, these oligoadenylates did not produce the characteristic RNase L activation footprints of ribosomal RNA cleavage HPLC analysis of extracts from interferon, virus-infected cells showed that while RNase L-activating trimer ppp(A20 p)2A and tetramer ppp(A20 p)3A were present, there were also present apparent 20 ,50 -oligoadenylates that competed with the above 2-5A activators, but themselves were only weak activators of RNase L.

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These inhibitory compounds of unknown structure could account for the poor activation of RNase L and the relative resistance of HSV-1 and HSV-2 to interferon in Chang cells One past observation is of special interest because the experiment was done in intact animals and involved an RNA virus rabies IFN administered intravenously, subcutaneously, or intraperitoneally to mice crosses the blood brain barrier to cause enhanced levels of the two double-stranded RNA-dependent enzymes, the protein kinase and 20 ,50 -oligoadenylate (2-5A) synthetase in the brain72,73 However, in spite of this effect, interferon seems to be unable to prevent the evolution of rabies disease in immunocompetent and immunosuppressed mice This may be Code 39 Full ASCII Creator In NET Framework Using 13 Supplement 5 In VS NET Using Barcode generation for ASP Related: .

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